CUL9 — Cullin 9
CUL9 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CUL9's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Chromatin transcription regulation DNA/chromatin regulation | ADAM10, CIRBP, CLIP1, GRPEL2, HBP1, KDM2A, NCOA3, NSD3 +10 more | View in SCUBA |
About the gene
| Synonyms | H7AP1, KIAA0708, PARC |
|---|---|
| Chromosome | 6: 43182184-43224587 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins |
| Molecular function | Transferase |
| Biological process | Ubl conjugation pathway |
Function
Core component of a Cul9-RING ubiquitin-protein ligase complex composed of CUL9 and RBX1. The CUL9-RBX1 complex mediates ubiquitination and subsequent degradation of BIRC5 and is required to maintain microtubule dynamics and genome integrity. Acts downstream of the 3M complex, which inhibits the ubiquitination of BIRC5. The CUL9-RBX1 complex also mediates mono- ubiquitination of p53/TP53. Acts as a cytoplasmic anchor protein in p53/TP53-associated protein complex. Regulates the subcellular localization of p53/TP53 and its subsequent function. Ubiquitinates apurinic/apyrimidinic endodeoxyribonuclease APEX2. Ubiquitination by the CUL9-RBX1 complex is predominantly mediated by E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2D2.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.