CLIP1 — CAP-Gly domain containing linker protein 1
CLIP1 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CLIP1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Chromatin transcription regulation DNA/chromatin regulation | ADAM10, CIRBP, CUL9, GRPEL2, HBP1, KDM2A, NCOA3, NSD3 +10 more | View in SCUBA |
| Endothelial | IL-13/STAT6 Signaling Inflammation | ABLIM1, ARL2BP, ASRGL1, ATP8B1, BMP1, BMPR2, CMIP, EHBP1L1 +18 more | View in SCUBA |
| Macrophages | RNA Processing Housekeeping Housekeeping | BAZ1A, BDP1, CCAR1, CCDC88A, CUL5, DHX36, DNM1L, EP400 +32 more | View in SCUBA |
| Neutrophils | Ubiquitin-Proteasome Turnover Housekeeping | BLTP3B, CACUL1, FBXL20, FBXO33, FGD3, IL18RAP, KIF13A, LMTK2 +10 more |
About the gene
| Synonyms | CLIP, CLIP-170, CLIP170, CYLN1, RSN |
|---|---|
| Chromosome | 12: 122271432-122422669 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Plasma proteins, Predicted intracellular proteins |
| Biological process | Transport |
Function
Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.