NSD3 — Nuclear receptor binding SET domain protein 3
NSD3 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NSD3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | BCR signaling/maturation B cell maturation | ATP6V0A1, BCL11A, CAMK2D, CD22, CLEC2D, DDHD1, DGKD, IL4R +9 more | View in SCUBA |
| CD4⁺ T cells | Chromatin transcription regulation DNA/chromatin regulation | ADAM10, CIRBP, CLIP1, CUL9, GRPEL2, HBP1, KDM2A, NCOA3 +10 more | View in SCUBA |
| Innate lymphoid cells | Cytoskeletal Remodeling Cytoskeleton & motility | BCLAF1, BPTF, CBL, CDK13, IQGAP2, KDM2A, KDM5A, LTC4S +8 more | View in SCUBA |
| Macrophages | RNA Processing Housekeeping Housekeeping | BAZ1A, BDP1, CCAR1, CCDC88A, CLIP1, CUL5, DHX36, DNM1L +32 more | View in SCUBA |
| Mucosal-associated invariant T cell | TGF-β Immune Regulation Immune regulation | ADAM12, AFF1, AKAP9, FNBP4, IKZF3, INPP4A, MAN1A1, PCNX1 +8 more | |
| Neutrophils | Apoptotic Neutrophil Program Developmental | ANO10, APAF1, ARFGEF1, ATF7IP, BLTP1, CEP350, FAR2, FBXW2 +5 more |
About the gene
| Synonyms | FLJ20353, KMT3F, WHISTLE, WHSC1L1 |
|---|---|
| Chromosome | 8: 38269704-38382272 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Chromatin regulator, Methyltransferase, Transferase |
| Biological process | Transcription, Transcription regulation |
Function
Histone methyltransferase. Preferentially dimethylates 'Lys- 4' and 'Lys-27' of histone H3 forming H3K4me2 and H3K27me2. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.