Chromatin transcription regulation
Gene co-expression module in CD4⁺ T cells
| Category | DNA/chromatin regulation |
|---|---|
| Genes | 19 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 19 genes have a known function matching the annotation |
Why this annotation
Dominated by transcriptional/chromatin regulators: PRDM2, HBP1, ZNF292, NSD3 (histone methyltransferase), KDM2A (demethylase), NCOA3 (coactivator), ZBTB20, with SF3B1 (splicing) and OTUD5/ZNRF2/CUL9 (ubiquitin). TULP4, CLIP1, PTTG1, RHOH. The hub genes are chromatin/transcription modifiers, suggesting a transcriptional regulation/chromatin program associated with T-cell activation in inflammation.
Genes
ADAM10, CIRBP, CLIP1, CUL9, GRPEL2, HBP1, KDM2A, NCOA3, NSD3, OTUD5, PRDM2, PTTG1, RHOH, SF3B1, TPP1, TULP4, ZBTB20, ZNF292, ZNRF2
Most correlated modules
- RNA & Chromatin Regulation · correlation 0.79
- CCR5 effector migration · correlation 0.77
- Epigenetic regulation · correlation 0.77
- Protein/ER secretory machinery · correlation 0.72
- Chromatin regulation · correlation 0.71
- PD-L1 checkpoint · correlation 0.71
- AKT survival signaling · correlation 0.70
- Regulatory T cell · correlation 0.69
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.