HBP1 — HMG-box transcription factor 1
HBP1 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
HBP1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Chromatin transcription regulation DNA/chromatin regulation | ADAM10, CIRBP, CLIP1, CUL9, GRPEL2, KDM2A, NCOA3, NSD3 +10 more | View in SCUBA |
| Gamma-delta T cells | ER Stress Response Stress | ATP1B3, ATP2A2, BACH1, CPD, EIF2AK3, FAM118A, G3BP2, GRK5 +13 more | |
| Lymphatic endothelial | DNA Damage Autophagy Stress | CKS2, COQ10B, GADD45A, MAP1LC3B, MSX1, NR1D1, PHLDA2, STX11 +2 more | View in SCUBA |
| Natural Killer cells | TGF-beta Repression DNA regulation & transcription | BZW1, GTF2B, ODC1, POLR2K, SKIL, SKP1, SPTY2D1, UBE2D3 | View in SCUBA |
About the gene
| Chromosome | 7: 107168961-107202522 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Transcription factors |
| Molecular function | DNA-binding, Repressor |
| Biological process | Transcription, Transcription regulation, Wnt signaling pathway |
Function
Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'- TTCATTCATTCA-3'. Binding to the histone H1.0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.