DHX34 — DExH-box helicase 34
DHX34 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DHX34's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | PI3K Lipid Signaling Innate immunity | AGPAT4, AREG, DNMBP, EEPD1, HIP1, IP6K1, IRAK2, JARID2 +23 more | View in SCUBA |
| Neutrophils | TLR2 Innate Signaling Innate immunity | AATK, CHST15, CYRIA, ECE1, ERGIC1, MAP4K4, MKNK1, STK40 +4 more |
About the gene
| Synonyms | DDX34, KIAA0134 |
|---|---|
| Chromosome | 19: 47349315-47382704 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Predicted intracellular proteins |
| Molecular function | Helicase, Hydrolase, RNA-binding |
Function
Probable ATP-binding RNA helicase required for nonsense- mediated decay (NMD) degradation of mRNA transcripts containing premature stop codons. Promotes the phosphorylation of UPF1 along with its interaction with key NMD pathway proteins UPF2 and EIF4A3. Interaction with the RUVBL1-RUVBL2 complex results in loss of nucleotide binding ability and ATP hydrolysis of the complex. Negatively regulates the nucleotide binding ability and ATP hydrolysis of the RUVBL1-RUVBL2 complex via induction of N-terminus conformation changes of the RUVBL2 subunits.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.