PI3K Lipid Signaling
Gene co-expression module in Macrophages
| Category | Innate immunity |
|---|---|
| Genes | 32 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 9 of 32 genes have a known function matching the annotation |
Why this annotation
PIK3R5 (PI3K p101 regulatory subunit, enriched in immune cells), VAV2 (Rho/Rac GEF downstream of PI3K), UBASH3B (ubiquitin/SH3 adaptor inhibiting immune receptor signaling), SIPA1L1 (Rap1 GAP), PRKAG2 (AMPK gamma subunit), AGPAT4 (lysophospholipid acyltransferase), PITPNC1 (phosphatidylinositol transfer protein), and SYTL3 (synaptotagmin-like vesicle regulator) collectively suggest PI3K-centered lipid/immune signaling. JARID2 (PRC2 chromatin) and MB21D2 (cGAS-like) add epigenetic/innate immune components. Strong mono_mac enrichment supports monocyte-specific PI3K/lipid signaling.
Genes
AGPAT4, AREG, DHX34, DNMBP, EEPD1, HIP1, IP6K1, IRAK2, JARID2, KCNK13, MB21D2, MICAL2, NEK1, PDE3B, PIK3R5, PITPNC1, PLA2G4A, PRKAG2, RFX2, SIK2, SIPA1L1, STAT4, SYTL3, TBC1D8, UBAP1, UBASH3B, UST, VAV2, WDR59, XYLT1, ZBTB46, ZHX2
Most correlated modules
- MAPK Stress Kinase · correlation 0.96
- Chromatin Epigenetic Regulation · correlation 0.94
- Rho GTPase Signaling · correlation 0.94
- Ubiquitin Proteasome Regulation · correlation 0.94
- Innate Immune Dampening · correlation 0.93
- Golgi Vesicle Trafficking · correlation 0.90
- NF-κB Inflammatory Activation · correlation 0.89
- Transcriptional Kinase Regulation · correlation 0.88
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.