HIP1 — Huntingtin interacting protein 1
HIP1 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
HIP1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | IL-13/STAT6 Signaling Inflammation | ABLIM1, ARL2BP, ASRGL1, ATP8B1, BMP1, BMPR2, CLIP1, CMIP +18 more | View in SCUBA |
| Lymphatic endothelial | Inflammatory cAMP Response Inflammation | ARL15, DIAPH2, EBF1, PDE4D, PDE7B, PELI2, PLCB4 | View in SCUBA |
| Macrophages | PI3K Lipid Signaling Innate immunity | AGPAT4, AREG, DHX34, DNMBP, EEPD1, IP6K1, IRAK2, JARID2 +23 more | View in SCUBA |
| Natural Killer cells | Hypoxia Response Stress | ANKRD28, ATP8B4, EPAS1, LPIN1, MAML3, MDFIC, RGS1, RHOQ +2 more | View in SCUBA |
| Smooth muscle cells | Pericyte Basement Membrane ECM remodeling | ACAN, ADCY6, ANGPT1, ATP8B1, COL18A1, CSPG4, ENTPD1, ITGA3 +7 more | View in SCUBA |
About the gene
| Synonyms | ILWEQ |
|---|---|
| Chromosome | 7: 75533298-75738962 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Potential drug targets, Predicted intracellular proteins, Transporters |
| Molecular function | Actin-binding, Activator |
| Biological process | Apoptosis, Differentiation, Endocytosis, Transcription, Transcription regulation |
Function
Plays a role in clathrin-mediated endocytosis and trafficking. Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner (By similarity). Regulates presynaptic nerve terminal activity (By similarity). Enhances androgen receptor (AR)- mediated transcription. May act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis. May play a functional role in the cell filament networks. May be required for differentiation, proliferation, and/or survival of somatic and germline progenitors.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.