JARID2 — Jumonji and AT-rich interaction domain containing 2
JARID2 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
JARID2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Epigenetic regulation DNA/chromatin regulation | AFF4, ARID1B, CTSA, DGKH, FUBP1, PDCD6, SYNCRIP, TET2 +6 more | View in SCUBA |
| Macrophages | PI3K Lipid Signaling Innate immunity | AGPAT4, AREG, DHX34, DNMBP, EEPD1, HIP1, IP6K1, IRAK2 +23 more | View in SCUBA |
| Monocytes | AMPK-FOXO Stress Response Stress | AHCTF1, C15orf39, FOXO3, FURIN, IRF2BP2, MIDN, PRKAG2, TLE3 | View in SCUBA |
| Mucosal-associated invariant T cell | Nuclear-Cytoplasmic Transport Housekeeping | AP1G1, CNOT1, INO80D, NAA50, NUP98, PLEKHA2, PLEKHM1, RANBP2 +3 more |
About the gene
| Synonyms | JMJ |
|---|---|
| Chromosome | 6: 15246069-15522042 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Human disease related genes, Plasma proteins, Predicted intracellular proteins, Transcription factors |
| Molecular function | Chromatin regulator, Developmental protein, Repressor |
| Biological process | Differentiation, Transcription, Transcription regulation |
Function
Regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis. Acts as an accessory subunit for the core PRC2 (Polycomb repressive complex 2) complex, which mediates histone H3K27 (H3K27me3) trimethylation on chromatin. Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells, thereby playing a key role in stem cell differentiation and normal embryonic development. In cardiac cells, it is required to repress expression of cyclin-D1 (CCND1) by activating methylation of 'Lys-9' of histone H3 (H3K9me) by the GLP1/EHMT1 and G9a/EHMT2 histone methyltransferases (By similarity). Also acts as a transcriptional repressor of ANF via its interaction with GATA4 and NKX2-5 (By similarity). Participates in the negative regulation of cell proliferation signaling (By similarity). Does not have histone demethylase activity (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.