DNMBP — Dynamin binding protein
DNMBP belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DNMBP's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Venous EC Identity Endothelial cell development | CAVIN2, CEACAM1, CYBA, EFCC1, EPHX1, GMFG, HID1, KANK3 +7 more | View in SCUBA |
| Macrophages | PI3K Lipid Signaling Innate immunity | AGPAT4, AREG, DHX34, EEPD1, HIP1, IP6K1, IRAK2, JARID2 +23 more | View in SCUBA |
| Monocytes | G-protein Membrane Remodeling Migration & adhesion | ADA, ANKRD9, CXCL16, EPB41L3, GFOD1, GNA12, GNA13, MRAS +7 more | View in SCUBA |
About the gene
| Synonyms | ARHGEF36, KIAA1010, Tuba |
|---|---|
| Chromosome | 10: 99875577-100009947 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins |
| Molecular function | Guanine-nucleotide releasing factor |
Function
Plays a critical role as a guanine nucleotide exchange factor (GEF) for CDC42 in several intracellular processes associated with the actin and microtubule cytoskeleton. Regulates the structure of apical junctions through F-actin organization in epithelial cells. Participates in the normal lumenogenesis of epithelial cell cysts by regulating spindle orientation. Plays a role in ciliogenesis (By similarity). May play a role in membrane trafficking between the cell surface and the Golgi (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.