AGPAT4 — 1-acylglycerol-3-phosphate O-acyltransferase 4
AGPAT4 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
AGPAT4's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | γδ T Cell Identity T cell maturation | AGAP1, C1orf21, CD226, CD47, GAS7, ITGA5, ITGAM, MYO1G +7 more | |
| Macrophages | PI3K Lipid Signaling Innate immunity | AREG, DHX34, DNMBP, EEPD1, HIP1, IP6K1, IRAK2, JARID2 +23 more | View in SCUBA |
About the gene
| Synonyms | dJ473J16.2, LPAAT-delta, LPAAT4, LPLAT4 |
|---|---|
| Chromosome | 6: 161129967-161274061 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Acyltransferase, Transferase |
| Biological process | Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism |
Function
Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (By similarity). Exhibits high acyl-CoA specificity for polyunsaturated fatty acyl-CoA, especially docosahexaenoyl-CoA (22:6-CoA, DHA-CoA) (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.