IRAK2 — Interleukin 1 receptor associated kinase 2
IRAK2 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
IRAK2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Lymphatic endothelial | NF-κB Innate Signaling Inflammation | AKAP13, B4GALT5, BACH1, CHD2, CNST, DENND5A, HIVEP1, HIVEP2 +11 more | View in SCUBA |
| Macrophages | PI3K Lipid Signaling Innate immunity | AGPAT4, AREG, DHX34, DNMBP, EEPD1, HIP1, IP6K1, JARID2 +23 more | View in SCUBA |
| Monocytes | NF-κB Signaling Inflammatory | BIRC3, ERN1, G0S2, ICAM1, IER3, NFKB1, PDE4B, PNRC1 +4 more | View in SCUBA |
| Neutrophils | NF-κB Signaling Inflammatory | ATP13A3, BMP6, DOCK4, DSE, FLT1, HIVEP2, KIFC3, MAML2 +2 more |
About the gene
| Chromosome | 3: 10164919-10243745 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Human disease related genes, Predicted intracellular proteins |
Function
Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.