DPY19L1 — Dpy-19 like C-mannosyltransferase 1
DPY19L1 belongs to a gene co-expression module in 1 of 30 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DPY19L1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Colonocytes | Epithelial Innate Immunity Inflammation | ADAM9, AGPAT4, ALOX5, ANXA1, ARFGAP3, ASPH, AZGP1, BACE2 +32 more | View in SCUBA |
About the gene
| Synonyms | KIAA0877 |
|---|---|
| Chromosome | 7: 34927292-35038271 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Glycosyltransferase, Transferase |
Function
C-mannosyltransferase that mediates the C-mannosylation tryptophan residues on target proteins. The reaction occurs on the luminal side of the endoplasmic reticulum and involves the transfer of a mannose unit from a dolichylphosphate mannose (Dol-P-Man) donor to an acceptor protein containing a WxxW consensus sequence (By similarity). C-mannosylates the first two tryptophans in the WxxWxxWxxC motif in thrombospondin (TSP) type-1 of UNC5A (By similarity). Regulates neurite extension during development (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.