Epithelial Innate Immunity
Gene co-expression module in Colonocytes
| Category | Inflammation |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 14 of 41 genes have a known function matching the annotation |
Why this annotation
This module is strongly enriched in inf_colono (inflamed colonocytes) and significantly upregulated in UC inflammation with reversal at remission. Hub genes include DUOXA2 (dual oxidase maturation factor, reactive oxygen species production), LCN2 (lipocalin-2, acute phase/antimicrobial), CXCL1 (neutrophil-attracting chemokine), PI3 (elafin/protease inhibitor), ANXA1 (anti-inflammatory annexin), SERPINA1 (alpha-1 antitrypsin), ALOX5 (arachidonate 5-lipoxygenase, leukotriene synthesis), TNIP3 (NF-kB inhibitor), SLC6A14 (amino acid transporter upregulated in inflammation). The module captures a broad epithelial innate immune/inflammatory response program in colonocytes, dominated by antimicrobial, oxidative, and chemokine-related genes. The coherence is core and all top genes are consistently enriched in inf_colono.
Genes
Most correlated modules
- Oxidative Inflammatory Remodeling · correlation 0.91
- Inflamed Barrier Remodeling · correlation 0.90
- Wound Regenerative Response · correlation 0.87
- Hypoxia-Inflammatory Reprogramming · correlation 0.84
- IFN-γ Antiviral Response · correlation 0.83
- Basement Membrane Remodeling · correlation 0.83
- MHC II Antigen Presentation · correlation 0.82
- Inflammatory Stress Response · correlation 0.80
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.