ERF — ETS2 repressor factor
ERF belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ERF's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Pol II Transcription Regulation DNA/chromatin regulation | ABHD5, BAIAP2, BRD2, CBX4, CDKN1C, CITED2, CKS2, EHD1 +28 more | View in SCUBA |
| Lymphatic endothelial | Stress Granule Assembly Stress | AMD1, BHLHE40, CD55, CDKN1A, DDX3X, DUSP5, EIF4G2, FUS +3 more | View in SCUBA |
About the gene
| Synonyms | PE-2, PE2 |
|---|---|
| Chromosome | 19: 42247569-42255128 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors |
| Molecular function | DNA-binding, Repressor |
| Biological process | Transcription, Transcription regulation |
Function
Potent transcriptional repressor that binds to the H1 element of the Ets2 promoter. May regulate other genes involved in cellular proliferation. Required for extraembryonic ectoderm differentiation, ectoplacental cone cavity closure, and chorioallantoic attachment (By similarity). May be important for regulating trophoblast stem cell differentiation (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.