FUS — FUS RNA binding protein

FUS belongs to a gene co-expression module in 13 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

FUS's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	ATF4 Stress Response Stress	ATF4, BRD2, CCNYL1, ERO1B, GLA, HMGCS1, INSIG1, KLF10 +3 more	View in SCUBA
CD4⁺ T cells	mRNA Splicing Factors RNA processing	ARGLU1, CDKN2D, CLK1, ERO1B, GLS, HNRNPA2B1, ID1, MAT2A +8 more	View in SCUBA
CD8⁺ T cells	Pre-mRNA Splicing RNA processing & translation	BRD2, EIF3A, HNRNPU, HSPA9, NCL, PNN, RBM25, RBM39 +5 more	View in SCUBA
Fibroblasts	Co-transcriptional RNA Processing Housekeeping	IFRD1, INTS6, PCF11, PPP1R10, RSRP1, TSPYL2, YME1L1	View in SCUBA
Glial cells	Anti-proliferative mRNA Decay Stress	ABHD5, BCL6, EIF4A1, GADD45A, MAT2A, PLK2, RBBP6, TOB1 +4 more	View in SCUBA
Goblet cells	RNA Splicing RNA processing & translation	ARGLU1, C6orf62, EPHB3, HNRNPH1, HNRNPU, LUC7L3, NOP53	View in SCUBA
Innate lymphoid cells	RNA-binding & Splicing RNA processing & translation	CALM1, DYNLL1, HNRNPA2B1, HNRNPAB, NCL, NUDC, PPIG, SAP18 +4 more	View in SCUBA
Lymphatic endothelial	Stress Granule Assembly Stress	AMD1, BHLHE40, CD55, CDKN1A, DDX3X, DUSP5, EIF4G2, ERF +3 more	View in SCUBA
Macrophages	Pre-mRNA Splicing Housekeeping	BCLAF1, CSNK1A1, DDX3X, DDX5, EWSR1, HNRNPH1, HNRNPH3, HNRNPU +11 more	View in SCUBA
Mucosal-associated invariant T cell	AP-1 Immediate Early Stress	AMD1, BRD2, CITED2, CSKMT, GADD45B, GADD45G, H2AX, HEXIM1 +17 more
Natural Killer cells	Transcription Elongation Control DNA regulation & transcription	C6orf62, FAM53C, HEXIM1, INTS6, MAT2A, NABP1, PCF11, PPP1R10 +2 more	View in SCUBA
Neutrophils	RNA Splicing Housekeeping	ATF4, HNRNPA2B1, HNRNPA3, IRF2BP2, SFPQ, SRSF3, TRA2B
Smooth muscle cells	Translation initiation/RNA-binding RNA processing & translation	BRI3, CDV3, EIF5, EPC1, FAM133B, FAM53C, MAFB, PPP1R10 +2 more	View in SCUBA

About the gene

Synonyms	ALS6, FUS1, hnRNP-P2, HNRNPP2, TLS
Chromosome	16: 31180138-31191605
Predicted location	Intracellular
Essential gene	No
Protein class	Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins
Molecular function	DNA-binding, RNA-binding

Function

DNA/RNA-binding protein that plays a role in various cellular processes such as transcription regulation, RNA splicing, RNA transport, DNA repair and damage response. Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3'. Binds to nascent pre-mRNAs and acts as a molecular mediator between RNA polymerase II and U1 small nuclear ribonucleoprotein thereby coupling transcription and splicing. Also binds its own pre- mRNA and autoregulates its expression; this autoregulation mechanism is mediated by non-sense-mediated decay. Plays a role in DNA repair mechanisms by promoting D-loop formation and homologous recombination during DNA double-strand break repair. In neuronal cells, plays crucial roles in dendritic spine formation and stability, RNA transport, mRNA stability and synaptic homeostasis (By similarity).

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.