Stress Granule Assembly

Gene co-expression module in Lymphatic endothelial

View this module in SCUBA

Why this annotation

Hub genes include CDKN1A (p21, canonical cell-cycle arrest and stress effector), DUSP5 (MAPK phosphatase, immediate-early stress/mitogen response), TRIB1 (stress-responsive pseudokinase), BHLHE40 (stress/hypoxia-responsive bHLH), DDX3X (RNA helicase involved in stress granules and translational control), EIF4G2 (translational repressor active under stress), FUS and SFPQ (RNA-binding proteins recruited to stress granules), AMD1 (polyamine synthesis, stress-regulated), MIDN (midnolin, proteasome-related stress response), ERF (ETS repressor). The combination of translational repressors, stress granule components, CDKN1A, and immediate-early kinase regulators points to a stress-induced translational arrest / stress granule program. Neighbor M47 (ISR) and M89 (IEG/AP-1) support a broader stress-response neighborhood.

Genes

AMD1, BHLHE40, CD55, CDKN1A, DDX3X, DUSP5, EIF4G2, ERF, FUS, MIDN, SFPQ, TRIB1

Most correlated modules

• NF-κB Inflammatory Activation · correlation 0.82
• Integrated Stress Response · correlation 0.82
• DNA Damage Response · correlation 0.76
• Hypoxic Stress Response · correlation 0.74
• Notch TGF-β Endothelial · correlation 0.73
• NF-κB Negative Feedback · correlation 0.70
• AP-1 Immediate Early · correlation 0.69
• DNA Damage Autophagy · correlation 0.67

Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.