SCUBA

EIF4G2 — Eukaryotic translation initiation factor 4 gamma 2

EIF4G2 belongs to a gene co-expression module in 12 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

EIF4G2's module in each cell type

Cell typeModuleShares the module with
CD4⁺ T cellsIL6-STAT3 Signaling
Intercellular communication
ARID5A, ARL6IP1, AZIN1, CCDC66, CDC40, CEMIP2, CHD1, CSNK1D +13 moreView in SCUBA
CD8⁺ T cellsChromatin RNA Processing
RNA processing & translation
CHD4, FLNA, GNB1, MTDH, SFPQ, SRSF11, UBXN4, ZNF207View in SCUBA
EndothelialEndocytic Membrane Remodeling
migration & adhesion
ARHGAP23, BNIP2, CDK17, HERC1, KCTD15, LPCAT1, LRRC8A, LUZP1 +4 moreView in SCUBA
Gamma-delta T cellsTranscription-RNA Coupling
DNA/chromatin regulation
AKNA, AP1G1, BTAF1, BZW1, CRNKL1, DDX6, DNTTIP2, DYNC1H1 +26 more
Glial cellsGlial Neural Scaffolding
Cytoskeletal
AKAP6, ARHGAP24, COL5A3, NFIX, PPP1R12B, SCAF11, SEMA6D, USP53View in SCUBA
Goblet cellsAdhesion & Transport
Cytoskeletal
AHCYL1, CHMP1B, DDX5, DYNC1H1, DYNC1LI2, ITGB1, PTTG1IP, SLC38A1 +4 moreView in SCUBA
Innate lymphoid cellsmRNA Stability & Splicing
RNA processing & translation
BUD31, GNAI3, HSPA9, PABPC1, PABPC4, PAIP2, PAPOLA, PRKAR1A +6 moreView in SCUBA
Lymphatic endothelialStress Granule Assembly
Stress
AMD1, BHLHE40, CD55, CDKN1A, DDX3X, DUSP5, ERF, FUS +3 moreView in SCUBA
MacrophagesActin Cytoskeleton Organization
Cytoskeletal
ACTR3, ARF1, ARHGDIA, ARPC4, CDC42, DERL1, GARS1, HNRNPK +20 moreView in SCUBA
Mucosal-associated invariant T cellNF-κB RNA Regulation
RNA processing & translation
ARIH2, ATP1A1, BCLAF1, BNIP2, CALR, COG3, DDX6, EIF4H +14 more
PericytesmRNA Stability Regulation
Housekeeping
ACTR2, HNRNPK, MTDH, MTPN, QKI, SERBP1, SETView in SCUBA
Smooth muscle cellsActin Cytoskeletal Scaffold
Cytoskeletal
ACTN4, ATP2B4, ATRX, DDX5, DLGAP4, FAT1, GNAI2, JAK1 +13 moreView in SCUBA

About the gene

SynonymsDAP5, NAT1, p97
Chromosome11: 10797050-10808940
Predicted locationIntracellular
Essential geneYes
Protein classEssential proteins, Plasma proteins, Predicted intracellular proteins
Molecular functionInitiation factor, Repressor
Biological processProtein biosynthesis, Translation regulation

Function

Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Cleaved by some caspases and viral proteases.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.