ESCO1 — Establishment of sister chromatid cohesion N-acetyltransferase 1
ESCO1 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ESCO1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Transcription/RNA processing RNA processing | ANKRD17, BDP1, CCDC97, CDK13, CHIC2, CLK4, CNOT6L, CRNKL1 +29 more | View in SCUBA |
About the gene
| Synonyms | EFO1, ESO1, KIAA1911 |
|---|---|
| Chromosome | 18: 21529284-21600884 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Metabolic proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Acyltransferase, Transferase |
| Biological process | Cell cycle |
Function
Acetyltransferase required for the establishment of sister chromatid cohesion. Couples the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during S phase. Acts by mediating the acetylation of cohesin component SMC3.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.