Transcription/RNA processing
Gene co-expression module in CD4⁺ T cells
| Category | RNA processing |
|---|---|
| Genes | 38 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 8 of 38 genes have a known function matching the annotation |
Why this annotation
Strong coherence module dominated by transcription/RNA-processing and chromatin regulators: CNOT6L (CCR4-NOT deadenylase), CDK13 (transcriptional CDK), RNMT (mRNA cap methyltransferase), CLK4 (splicing kinase), CDK13, EPC1 (NuA4/Tip60 HAT), MSL2 and KANSL1 (MSL/NSL histone acetylation complexes), BDP1 (RNA Pol III), ELF1 (TF), TMF1. This is a coherent transcription/RNA-processing and chromatin-modifying program. RNMT, CLK4, CNOT6L, BDP1 are clearly RNA-related; MSL2/KANSL1/EPC1 are chromatin. Calling RNA processing as the dominant theme.
Genes
ANKRD17, BDP1, CCDC97, CDK13, CHIC2, CLK4, CNOT6L, CRNKL1, ELF1, EPC1, ESCO1, EVI2A, GPATCH2, GXYLT1, ITK, JMY, KANSL1, MRPL1, MSL2, MTMR6, PPIL4, PPP1R2, PPP4R3A, RB1CC1, RNMT, RPL7L1, SCAF11, SERINC1, SIK3, SPG7, TBC1D15, TMF1, UBR5, WDR82, ZDBF2, ZFAND6, ZKSCAN1, ZNF451
Most correlated modules
- Cell cycle regulators · correlation 0.78
- mRNA splicing · correlation 0.77
- Post-transcriptional regulation · correlation 0.76
- DNA repair/replication · correlation 0.69
- TCR signaling activation · correlation 0.68
- IL6-STAT3 Signaling · correlation 0.60
- Integrin adhesion · correlation 0.60
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.