F8 — Coagulation factor VIII
F8 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
F8's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Lymphatic endothelial | Endothelial Identity endothelial development | CHST12, ENDOD1, EPHB4, F2R, GALNT1, KDR, NR2F2, PECAM1 +4 more | View in SCUBA |
About the gene
| Synonyms | DXS1253E, F8C, FVIII, HEMA |
|---|---|
| Chromosome | X: 154835788-155026940 |
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Candidate cardiovascular disease genes, Disease related genes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins |
| Biological process | Acute phase, Blood coagulation, Hemostasis |
Function
Factor VIII, along with calcium and phospholipid, acts as a cofactor for F9/factor IXa when it converts F10/factor X to the activated form, factor Xa
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.