CHST12 — Carbohydrate sulfotransferase 12
CHST12 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CHST12's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD8⁺ T cells | Terminal Exhaustion Exhaustion | ACP5, CARD16, CASP1, CD2, CD247, CD8A, CD8B, CXCR6 +6 more | View in SCUBA |
| Gamma-delta T cells | T-bet Effector Differentiation T cell maturation | ABHD17A, BCL7C, CAPNS1, DGKZ, EFHD2, FMNL1, GNAI2, GNB2 +15 more | |
| Hematopoietic progenitor cells | Biosynthetic Housekeeping Housekeeping | BZW2, CREG1, EEF1B2, FBL, HNRNPA1, HSP90AB1, IMPDH2, LDHB +7 more | |
| Lymphatic endothelial | Endothelial Identity endothelial development | ENDOD1, EPHB4, F2R, F8, GALNT1, KDR, NR2F2, PECAM1 +4 more | View in SCUBA |
| Mucosal-associated invariant T cell | Type I Interferon Inflammation | ABCF2, ACAA2, ANXA2R, BST2, IRF9, LY6E, LYSMD2, NDUFC2 +6 more |
About the gene
| Synonyms | C4S-2, C4ST2 |
|---|---|
| Chromosome | 7: 2403588-2448484 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted membrane proteins |
| Molecular function | Transferase |
| Biological process | Carbohydrate metabolism |
Function
Catalyzes the transfer of sulfate to position 4 of the N- acetylgalactosamine (GalNAc) residue of chondroitin and desulfated dermatan sulfate. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Activity toward partially desulfated dermatan sulfate is however lower. Does not form 4, 6-di-O- sulfated GalNAc when chondroitin sulfate C is used as an acceptor
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.