Endothelial Identity
Gene co-expression module in Lymphatic endothelial
| Category | endothelial development |
|---|---|
| Genes | 13 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 9 of 13 genes have a known function matching the annotation |
Why this annotation
Hub genes PECAM1, TIE1, KDR, EPHB4, NR2F2, and PLXND1 are canonical endothelial identity and vascular development markers. NR2F2/COUP-TFII specifies venous and lymphatic identity. EPHB4 marks venous endothelium. F8 is produced by endothelial cells. CHST12 and SULF2 modify heparan sulfate proteoglycans critical for VEGF signaling. This module represents a core endothelial/vascular identity program, consistent with the lymphatic endothelial cell context. Neighbor M35 shares FLT4/VEGFR3 and vascular TFs, reinforcing the endothelial development neighborhood.
Genes
CHST12, ENDOD1, EPHB4, F2R, F8, GALNT1, KDR, NR2F2, PECAM1, PLXND1, SULF2, TIE1, TXNIP
Most correlated modules
- Anticoagulant Barrier · correlation 0.90
- Innate Immune Activation · correlation 0.90
- Lymphangiogenesis ECM · correlation 0.89
- Vascular Lumen Formation · correlation 0.88
- Lymphatic Vascular Stability · correlation 0.87
- Lymphatic Specification · correlation 0.86
- Septin Cytoskeleton · correlation 0.82
- Actin Cytoskeletal Scaffold · correlation 0.80
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.