KDR — Kinase insert domain receptor
KDR belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
KDR's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Angiogenic Endothelial Identity Endothelial cell development | ADAMTSL2, ARHGAP29, COL13A1, CTNNB1, EDIL3, EML1, ETS1, EXOC3L1 +14 more | View in SCUBA |
| Lymphatic endothelial | Endothelial Identity endothelial development | CHST12, ENDOD1, EPHB4, F2R, F8, GALNT1, NR2F2, PECAM1 +4 more | View in SCUBA |
| Pericytes | Angiogenic Receptor Signaling Developmental | ADGRG1, CPLX1, EPHB4, MGAT4A, PLXNA2, RASGRP3, ROBO4, SLCO2A1 +1 more | View in SCUBA |
About the gene
| Synonyms | CD309, FLK1, VEGFR, VEGFR2 |
|---|---|
| Chromosome | 4: 55078481-55125595 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Cancer-related genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted membrane proteins, RAS pathway related proteins |
| Molecular function | Developmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase |
| Biological process | Angiogenesis, Differentiation, Host-virus interaction |
Function
Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and VEGFD. Plays an essential role in the regulation of angiogenesis, vascular development, vascular permeability, and embryonic hematopoiesis. Promotes proliferation, survival, migration and differentiation of endothelial cells. Promotes reorganization of the actin cytoskeleton. Isoforms lacking a transmembrane domain, such as isoform 2 and isoform 3, may function as decoy receptors for VEGFA, VEGFC and/or VEGFD. Isoform 2 plays an important role as negative regulator of VEGFA- and VEGFC-mediated lymphangiogenesis by limiting the amount of free VEGFA and/or VEGFC and preventing their binding to FLT4. Modulates FLT1 and FLT4 signaling by forming heterodimers. Binding of vascular growth factors to isoform 1 leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, reorganization of the actin cytoskeleton and activation of PTK2/FAK1. Required for VEGFA-mediated induction of NOS2 and NOS3, leading to the production of the signaling molecule nitric oxide (NO) by endothelial cells. Phosphorylates PLCG1. Promotes phosphorylation of FYN, NCK1, NOS3, PIK3R1, PTK2/FAK1 and SRC.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.