NR2F2 — Nuclear receptor subfamily 2 group F member 2
NR2F2 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NR2F2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Venous EC Identity Endothelial cell development | ACTN1, AK4, CCL14, CTTNBP2, DAPK1, EPB41L3, FAM171A1, IL1R1 +18 more | View in SCUBA |
| Fibroblasts | Subepithelial Fibroblast Identity Developmental | ANGPTL1, APBB1IP, ARHGAP15, CNTN1, CP, ECM2, EFEMP1, FAM107A +12 more | View in SCUBA |
| Glial cells | Inflammatory Activation Response Inflammation | ANGPTL4, C11orf96, CD83, CEBPD, ENY2, GEM, IDI1, IRF9 +3 more | View in SCUBA |
| Lymphatic endothelial | Endothelial Identity endothelial development | CHST12, ENDOD1, EPHB4, F2R, F8, GALNT1, KDR, PECAM1 +4 more | View in SCUBA |
| Pericytes | Pericyte Identity Differentiation Developmental | ADAMTS5, ARHGAP15, EPB41L2, GUCY1A1, INPP4B, LGI4, LMOD1, MAP1LC3A +11 more | View in SCUBA |
| Smooth muscle cells | Vascular Tone Signaling Contractility | ADCY3, CPEB4, CYSTM1, DBI, EPAS1, EPS8, IER5L, PDE3A +5 more | View in SCUBA |
About the gene
| Synonyms | ARP1, COUP-TFII, COUPTF2, COUPTFB, NF-E3, SVP40, TFCOUP2 |
|---|---|
| Chromosome | 15: 96325938-96340263 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Nuclear receptors, Predicted intracellular proteins, Transcription factors |
| Molecular function | Activator, DNA-binding, Receptor |
| Biological process | Transcription, Transcription regulation |
Function
Ligand-activated transcription factor. Activated by high concentrations of 9-cis-retinoic acid and all-trans-retinoic acid, but not by dexamethasone, cortisol or progesterone (in vitro). Regulation of the apolipoprotein A-I gene transcription. Binds to DNA site A. May be required to establish ovary identity during early gonad development.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.