FAR2 — Fatty acyl-CoA reductase 2
FAR2 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
FAR2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Epithelial polarity cytoskeleton Cytoskeletal | ARHGEF10L, ARID5B, CADPS2, CLMN, DGKH, LLGL2, PLEKHA5, PLEKHG1 +3 more | View in SCUBA |
| Neutrophils | Apoptotic Neutrophil Program Developmental | ANO10, APAF1, ARFGEF1, ATF7IP, BLTP1, CEP350, FBXW2, HIPK2 +5 more |
About the gene
| Synonyms | FLJ10462, MLSTD1, SDR10E2 |
|---|---|
| Chromosome | 12: 29149016-29341121 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Oxidoreductase |
| Biological process | Lipid biosynthesis, Lipid metabolism |
Function
Catalyzes the reduction of saturated but not unsaturated C16 or C18 fatty acyl-CoA to fatty alcohols (FAls). A lower activity can be observed with shorter fatty acyl-CoA substrates. Can produce very long-chain and ultra long-chain FAls, regardless of whether they have a straight or branched chain. Involved in the production of ether lipids/plasmalogens and wax monoesters whose synthesis requires FAls as substrates.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.