DGKH — Diacylglycerol kinase eta
DGKH belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DGKH's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Epigenetic regulation DNA/chromatin regulation | AFF4, ARID1B, CTSA, FUBP1, JARID2, PDCD6, SYNCRIP, TET2 +6 more | View in SCUBA |
| Endothelial | Inflammatory Kinase Signaling Inflammation | ANKRD28, CBL, CDC123, CNN2, EOGT, FADS3, FYN, MAP4K4 +7 more | View in SCUBA |
| Enterocytes | Epithelial polarity cytoskeleton Cytoskeletal | ARHGEF10L, ARID5B, CADPS2, CLMN, FAR2, LLGL2, PLEKHA5, PLEKHG1 +3 more | View in SCUBA |
| Gamma-delta T cells | T Cell Exhaustion Exhaustion | AKAP5, AOAH, CCDC141, CD8A, CD8B, CDYL, CRTAM, CYSTM1 +20 more |
About the gene
| Synonyms | DGKeta |
|---|---|
| Chromosome | 13: 42040036-42256578 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted intracellular proteins |
| Molecular function | Kinase, Transferase |
| Biological process | Lipid metabolism |
Function
Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids. Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). Plays a key role in promoting cell growth. Activates the Ras/B-Raf/C-Raf/MEK/ERK signaling pathway induced by EGF. Regulates the recruitment of RAF1 and BRAF from cytoplasm to membranes and their heterodimerization.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.