LLGL2 — LLGL scribble cell polarity complex component 2
LLGL2 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
LLGL2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Epithelial polarity cytoskeleton Cytoskeletal | ARHGEF10L, ARID5B, CADPS2, CLMN, DGKH, FAR2, PLEKHA5, PLEKHG1 +3 more | View in SCUBA |
| Gamma-delta T cells | T-bet Effector Differentiation T cell maturation | ABHD17A, BCL7C, CAPNS1, CHST12, DGKZ, EFHD2, FMNL1, GNAI2 +15 more |
About the gene
| Synonyms | HGL, Hugl-2 |
|---|---|
| Chromosome | 17: 75525080-75575209 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Biological process | Cell cycle, Cell division, Exocytosis |
Function
Part of a complex with GPSM2/LGN, PRKCI/aPKC and PARD6B/Par- 6, which may ensure the correct organization and orientation of bipolar spindles for normal cell division. This complex plays roles in the initial phase of the establishment of epithelial cell polarity
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.