Epithelial polarity cytoskeleton
Gene co-expression module in Enterocytes
| Category | Cytoskeletal |
|---|---|
| Genes | 12 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 12 genes have a known function matching the annotation |
Why this annotation
LLGL2 (apical-basal polarity), SYNE2, PLEKHA5, CLMN, ARHGEF10L and PLEKHG1 (Rho GEFs) point to cytoskeletal polarity and membrane organization. STK39 (ion transport kinase), CADPS2, FAR2 and DGKH suggest mature epithelial membrane function. Overall this reads as a differentiated epithelial polarity and cytoskeleton program.
Genes
ARHGEF10L, ARID5B, CADPS2, CLMN, DGKH, FAR2, LLGL2, PLEKHA5, PLEKHG1, STK39, SYNE2, WWP1
Most correlated modules
- Long-gene intronic signal · correlation 0.89
- Transit-amplifying progenitor · correlation 0.84
- Crypt CFTR secretion · correlation 0.78
- Focal adhesion actin · correlation 0.77
- IFN-gamma immunoproteasome · correlation 0.71
- Crypt antimicrobial progenitor · correlation 0.70
- Cortical actin junctions · correlation 0.65
- Epithelial NF-kB response · correlation 0.62
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.