FCN1 — Ficolin 1
FCN1 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
FCN1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Monocytes | Monocyte Innate Surveillance Innate immunity | CDKN2D, ICAM3, MMP25, PADI2, RPH3A, S100P, TESC, TUBA4A | View in SCUBA |
About the gene
| Synonyms | FCNM |
|---|---|
| Chromosome | 9: 134903232-134917912 |
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted secreted proteins |
| Biological process | Immunity, Innate immunity |
Function
Extracellular lectin functioning as a pattern-recognition receptor in innate immunity. Binds the sugar moieties of pathogen- associated molecular patterns (PAMPs) displayed on microbes and activates the lectin pathway of the complement system. May also activate monocytes through a G protein-coupled receptor, FFAR2, inducing the secretion of interleukin-8/IL-8. Binds preferentially to 9-O-acetylated 2-6-linked sialic acid derivatives and to various glycans containing sialic acid engaged in a 2-3 linkage
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.