TUBA4A — Tubulin alpha 4a
TUBA4A belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TUBA4A's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | mRNA splicing factors RNA processing | CALM1, CALM2, CKS2, CYCS, EIF4A3, HNRNPA0, HNRNPA2B1, HNRNPAB +12 more | View in SCUBA |
| Gamma-delta T cells | TGF-beta Response Immune regulation | ADGRE5, CD83, CHMP1B, CHST7, DDIT3, DNAAF2, EHD4, FAM43A +15 more | |
| Hematopoietic progenitor cells | Platelet Biogenesis Myeloid development | CAVIN2, CCL5, CMTM5, F13A1, GNG11, GP9, MAP3K7CL, NRGN +6 more | |
| Innate lymphoid cells | mTOR Stress Response Stress | CEBPB, DDIT3, DDIT4, GLS, ID1, IFRD1, INTS6, JMJD6 +9 more | View in SCUBA |
| Monocytes | Monocyte Innate Surveillance Innate immunity | CDKN2D, FCN1, ICAM3, MMP25, PADI2, RPH3A, S100P, TESC | View in SCUBA |
| Natural Killer cells | AP-1 Immediate Early activation | BTG1, CITED2, CXCR4, DUSP1, DUSP2, FOS, JUN, JUNB +1 more | View in SCUBA |
About the gene
| Synonyms | FLJ30169, H2-ALPHA, TUBA1 |
|---|---|
| Chromosome | 2: 219249710-219277902 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Hydrolase |
Function
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.