RPH3A — Rabphilin 3A
RPH3A belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RPH3A's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Monocytes | Monocyte Innate Surveillance Innate immunity | CDKN2D, FCN1, ICAM3, MMP25, PADI2, S100P, TESC, TUBA4A | View in SCUBA |
About the gene
| Synonyms | exophilin-1, KIAA0985, rabphilin |
|---|---|
| Chromosome | 12: 112570380-112898881 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Biological process | Protein transport, Transport |
Function
Plays an essential role in docking and fusion steps of regulated exocytosis (By similarity). At the presynaptic level, RPH3A is recruited by RAB3A to the synaptic vesicle membrane in a GTP- dependent manner where it modulates synaptic vesicle trafficking and calcium-triggered neurotransmitter release (By similarity). In the post-synaptic compartment, forms a ternary complex with GRIN2A and DLG4 and regulates NMDA receptor stability. Also plays a role in the exocytosis of arginine vasopressin hormone (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.