FCRL5 — Fc receptor like 5
FCRL5 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
FCRL5's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Atypical memory B cell B cell maturation | FGR, HCK, HEXA, HMOX1, ITGAX, LRRK2, MED13L, NBEAL2 +5 more | View in SCUBA |
About the gene
| Synonyms | BXMAS1, CD307e, FCRH5, IRTA2 |
|---|---|
| Chromosome | 1: 157513377-157552515 |
| Predicted location | Membrane, Secreted |
| Essential gene | No |
| Protein class | CD markers, Disease related genes, Predicted membrane proteins, Predicted secreted proteins |
| Molecular function | Receptor |
| Biological process | Fertilization |
Function
Plays an important role in B-cell response to antigen that acts both as a negative or positive coreceptor. Inhibits B-cell receptor (BCR) signaling in the absence of CR2 stimulation but engagement with CR2 and the BCR lead to a superior calcium response compared to CR2 and BCR costimulation. May be involved in B-cell development and differentiation in peripheral lymphoid organs and may be useful markers of B-cell stages. May have an immunoregulatory role in marginal zone B-cells. May play a role in fertilization (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.