HCK — HCK proto-oncogene, Src family tyrosine kinase
HCK belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
HCK's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Atypical memory B cell B cell maturation | FCRL5, FGR, HEXA, HMOX1, ITGAX, LRRK2, MED13L, NBEAL2 +5 more | View in SCUBA |
| Macrophages | Lysosomal Hydrolase Program Lysosomal & pahgocytosis | AMDHD2, ARL6IP5, ARPIN, ARSA, CD81, CLDN7, CLEC2B, COMT +35 more | View in SCUBA |
| Monocytes | Myeloid Innate Receptor Signaling Innate immunity | CYTIP, JPT1, LILRA5, LILRB2, MYD88, PAG1, PILRA, SERPINA1 | View in SCUBA |
About the gene
| Synonyms | JTK9 |
|---|---|
| Chromosome | 20: 32052197-32101856 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Kinase, Transferase, Tyrosine-protein kinase |
| Biological process | Exocytosis, Host-virus interaction, Immunity, Inflammatory response, Innate immunity, Phagocytosis |
Function
Non-receptor tyrosine-protein kinase found in hematopoietic cells that transmits signals from cell surface receptors and plays an important role in the regulation of innate immune responses, including neutrophil, monocyte, macrophage and mast cell functions, phagocytosis, cell survival and proliferation, cell adhesion and migration. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as FCGR1A and FCGR2A, but also CSF3R, PLAUR, the receptors for IFNG, IL2, IL6 and IL8, and integrins, such as ITGB1 and ITGB2. During the phagocytic process, mediates mobilization of secretory lysosomes, degranulation, and activation of NADPH oxidase to bring about the respiratory burst. Plays a role in the release of inflammatory molecules. Promotes reorganization of the actin cytoskeleton and actin polymerization, formation of podosomes and cell protrusions. Inhibits TP73-mediated transcription activation and TP73-mediated apoptosis. Phosphorylates CBL in response to activation of immunoglobulin gamma Fc region receptors. Phosphorylates ADAM15, BCR, ELMO1, FCGR2A, GAB1, GAB2, RAPGEF1, STAT5B, TP73, VAV1 and WAS.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.