ITGAX — Integrin subunit alpha X
ITGAX belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ITGAX's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Atypical memory B cell B cell maturation | FCRL5, FGR, HCK, HEXA, HMOX1, LRRK2, MED13L, NBEAL2 +5 more | View in SCUBA |
| Gamma-delta T cells | NK-like Mature gd-T cytotoxicity | ABHD2, ATG9A, CEP78, HAVCR2, HSH2D, IFIT2, KIR2DL1, KIR2DL3 +14 more | |
| Macrophages | Inflammatory Monocyte Activation Inflammatory | ACTN1, ADAM8, AGTRAP, ANXA2, ANXA4, C15orf48, CD44, CD9 +21 more | View in SCUBA |
| Monocytes | TREM1 Inflammatory Signaling Innate immunity | AGO2, AKAP12, ATP2B1, B3GNT5, BTG1, C17orf107, CHRNE, ERRFI1 +6 more | View in SCUBA |
| Natural Killer cells | NK Cell Activation activation | AHNAK, AKT3, ANXA1, C16orf54, C1orf162, CD226, CD300A, PLAC8 +2 more | View in SCUBA |
| Neutrophils | Myeloid Inflammatory Activation Inflammatory | AQP9, CPD, FPR1, LITAF, MXD1, NABP1, NAMPT, SDCBP +5 more |
About the gene
| Synonyms | CD11C |
|---|---|
| Chromosome | 16: 31355134-31382999 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | CD markers, FDA approved drug targets, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Integrin, Receptor |
| Biological process | Cell adhesion |
Function
Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.