FGR — FGR proto-oncogene, Src family tyrosine kinase
FGR belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
FGR's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Atypical memory B cell B cell maturation | FCRL5, HCK, HEXA, HMOX1, ITGAX, LRRK2, MED13L, NBEAL2 +5 more | View in SCUBA |
| Endothelial | EC Barrier Integrity Endothelial cell development | ABCB1, ADCY4, AQP3, ARHGAP31, CRYBG3, EPS8, FRYL, GULP1 +14 more | View in SCUBA |
| Gamma-delta T cells | TCR Proximal Signaling TCR Signaling | ADGRG5, BIN2, C11orf21, C12orf75, CD300A, GPSM3, LAT, MATK +11 more | |
| Hematopoietic progenitor cells | ILC3/γδT Priming Lymphcyte development | C2CD4D, CCL1, CCR1, CD2, CD7, CHI3L2, GPR18, IL17RE +8 more | |
| Macrophages | SPP1 Tissue Remodeling ECM remodeling | BST1, CD52, CHI3L1, CHIT1, CSF1, FBP1, FN1, GCHFR +19 more | View in SCUBA |
| Natural Killer cells | NK Lymphocyte Survival Immune regulation | DENND2D, GIMAP1, GIMAP4, GIMAP7, IL16, PTGDR, SLAMF6, TRAF3IP3 | View in SCUBA |
About the gene
| Synonyms | c-fgr, p55c-fgr, SRC2 |
|---|---|
| Chromosome | 1: 27612064-27635185 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Kinase, Transferase, Tyrosine-protein kinase |
| Biological process | Immunity, Innate immunity |
Function
Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors devoid of kinase activity and contributes to the regulation of immune responses, including neutrophil, monocyte, macrophage and mast cell functions, cytoskeleton remodeling in response to extracellular stimuli, phagocytosis, cell adhesion and migration. Promotes mast cell degranulation, release of inflammatory cytokines and IgE-mediated anaphylaxis. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as MS4A2/FCER1B, FCGR2A and/or FCGR2B. Acts downstream of ITGB1 and ITGB2, and regulates actin cytoskeleton reorganization, cell spreading and adhesion. Depending on the context, activates or inhibits cellular responses. Functions as a negative regulator of ITGB2 signaling, phagocytosis and SYK activity in monocytes. Required for normal ITGB1 and ITGB2 signaling, normal cell spreading and adhesion in neutrophils and macrophages. Functions as a positive regulator of cell migration and regulates cytoskeleton reorganization via RAC1 activation. Phosphorylates SYK (in vitro) and promotes SYK-dependent activation of AKT1 and MAP kinase signaling. Phosphorylates PLD2 in antigen-stimulated mast cells, leading to PLD2 activation and the production of the signaling molecules lysophosphatidic acid and diacylglycerol. Promotes activation of PIK3R1. Phosphorylates FASLG, and thereby regulates its ubiquitination and subsequent internalization. Phosphorylates ABL1. Promotes phosphorylation of CBL, CTTN, PIK3R1, PTK2/FAK1, PTK2B/PYK2 and VAV2. Phosphorylates HCLS1 that has already been phosphorylated by SYK, but not unphosphorylated HCLS1. Together with CLNK, it acts as a negative regulator of natural killer cell-activating receptors and inhibits interferon-gamma production (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.