Atypical memory B cell
Gene co-expression module in CD19⁺ B cells
| Category | B cell maturation |
|---|---|
| Genes | 14 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 14 genes have a known function matching the annotation |
Why this annotation
Top hub genes ITGAX (CD11c), FCRL5, ZEB2, TET2 are canonical markers of age-associated/atypical 'double-negative' memory B cells (CD11c+ T-bet+ ABCs). Accompanied by myeloid-like kinases (HCK, FGR) typical of this B-cell subset. NKG7 is moderate (peripheral). Strongly defines the atypical/age-associated B cell program, expanded in inflammation.
Genes
FCRL5, FGR, HCK, HEXA, HMOX1, ITGAX, LRRK2, MED13L, NBEAL2, NKG7, PIKFYVE, PRKX, TET2, ZEB2
Most correlated modules
- Activated B cell · correlation 0.88
- B-cell activation · correlation 0.87
- Tissue-resident memory B · correlation 0.84
- B cell activation · correlation 0.81
- Oxidative/ER stress · correlation 0.79
- Lysosomal proteases · correlation 0.78
- ER/vesicle trafficking · correlation 0.73
- TNF/NF-kB response · correlation 0.73
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.