HMOX1 — Heme oxygenase 1
HMOX1 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
HMOX1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Atypical memory B cell B cell maturation | FCRL5, FGR, HCK, HEXA, ITGAX, LRRK2, MED13L, NBEAL2 +5 more | View in SCUBA |
| Endothelial | Inflammatory EC Activation Inflammation | ANGPT2, B3GNT5, BAIAP2, EPHA2, GMFB, HIC1, JUP, LPIN2 +6 more | View in SCUBA |
| Fibroblasts | Hypoxia Metabolic Stress Stress | ABL2, DYRK3, EMP1, ERRFI1, NFATC1, PFKFB3, PIM1, SERPINE1 +3 more | View in SCUBA |
| Gamma-delta T cells | IRF4 T-cell Activation T cell maturation | APOA1, APOA4, CD59, FCER1G, FES, FUCA1, GEM, GRAMD2B +14 more | |
| Lymphatic endothelial | NRF2 Oxidative Stress Stress | ATP1B3, F3, GCLM, GRPEL1, PLIN2, SLC3A2, TXNRD1 | View in SCUBA |
| Macrophages | NRF2 Oxidative Stress Stress | ACOT9, AHRR, ARMC9, BASP1, CARD19, CCDC71L, CD226, CLDND1 +27 more | View in SCUBA |
| Neutrophils | Heat Shock Response Stress | ATP6V0C, CYB5D1, DNAJA1, DUSP2, GNG10, HSP90AA1, HSP90AB1, HSPA1A +4 more |
About the gene
| Synonyms | bK286B10, HO-1 |
|---|---|
| Chromosome | 22: 35380361-35394214 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Oxidoreductase |
| Biological process | Apoptosis, Host-virus interaction |
Function
Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron. Affords protection against programmed cell death and this cytoprotective effect relies on its ability to catabolize free heme and prevent it from sensitizing cells to undergo apoptosis. (Microbial infection) During SARS-COV-2 infection, promotes SARS-CoV-2 ORF3A-mediated autophagy but is unlikely to be required for ORF3A-mediated induction of reticulophagy. Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.