FRAT1 — FRAT regulator of WNT signaling pathway 1
FRAT1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
FRAT1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | RNA processing RNA processing | AARSD1, ABHD14A, AMD1, CALM2, CDKN2AIP, CHMP1B, HNRNPAB, HNRNPDL +7 more | View in SCUBA |
| Gamma-delta T cells | AP-1 Immediate Early Response Stress | BRD2, CITED2, CSKMT, EGR1, EIF4A2, FRAT2, GADD45B, HEXIM1 +25 more |
About the gene
| Chromosome | 10: 97319271-97321915 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Biological process | Wnt signaling pathway |
Function
Positively regulates the Wnt signaling pathway by stabilizing beta-catenin through the association with GSK-3. May play a role in tumor progression and collaborate with PIM1 and MYC in lymphomagenesis
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.