CITED2 — Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2

CITED2 belongs to a gene co-expression module in 12 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

CITED2's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	Immediate early response Stress	ABHD5, CEBPB, FAM53C, GADD45A, GADD45B, HEXIM1, HSPA2, IER5L +9 more	View in SCUBA
CD4⁺ T cells	Pol II Transcription Regulation DNA/chromatin regulation	ABHD5, BAIAP2, BRD2, CBX4, CDKN1C, CKS2, EHD1, EIF4A1 +28 more	View in SCUBA
CD8⁺ T cells	TCR Complex Signaling TCR Signaling	ACAP1, ANXA1, CD37, CD3E, DUSP1, EVL, LAPTM5, LCK +4 more	View in SCUBA
Fibroblasts	Hypoxia-driven EMT Stress	ARC, CSKMT, DDIT4, FAM43A, FAM53C, HBEGF, HEXIM1, IER5L +7 more	View in SCUBA
Gamma-delta T cells	AP-1 Immediate Early Response Stress	BRD2, CSKMT, EGR1, EIF4A2, FRAT1, FRAT2, GADD45B, HEXIM1 +25 more
Glial cells	Hypoxia mTOR Stress Stress	AMD1, CDKN2AIP, DDIT4, HEXIM1, HSPA2, IFRD1, INTS6, NEU1 +3 more	View in SCUBA
Hematopoietic progenitor cells	HPC Stemness Program Stemness	AMHR2, ARMC8, CASP3, CNRIP1, CSF2RB, DLC1, FBXO7, HBS1L +3 more
Innate lymphoid cells	ILC3 identity Differentiation	BHLHE40, BRD4, CASK, GLUL, GNAS, HECA, IGFBP7, IQGAP1 +19 more	View in SCUBA
Lymphatic endothelial	DNA Damage Response DNA/chromatin regulation	BRD2, BTG2, H2AX, HBEGF, HEXIM1, INTS6, MAFB, NR4A1 +7 more	View in SCUBA
Macrophages	Anti-inflammatory Response Inflammatory	AMPD2, ARRDC2, BHLHE40, CBX4, CDKN1B, CEBPD, DENND3, EIF4B +31 more	View in SCUBA
Mucosal-associated invariant T cell	AP-1 Immediate Early Stress	AMD1, BRD2, CSKMT, FUS, GADD45B, GADD45G, H2AX, HEXIM1 +17 more
Natural Killer cells	AP-1 Immediate Early activation	BTG1, CXCR4, DUSP1, DUSP2, FOS, JUN, JUNB, KLF6 +1 more	View in SCUBA

About the gene

Synonyms	MRG1
Chromosome	6: 139371807-139374648
Predicted location	Intracellular
Essential gene	No
Protein class	Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins
Molecular function	Activator, Developmental protein, Repressor
Biological process	Differentiation, Stress response, Transcription, Transcription regulation

Function

Transcriptional coactivator of the p300/CBP-mediated transcription complex. Acts as a bridge, linking TFAP2 transcription factors and the p300/CBP transcriptional coactivator complex in order to stimulate TFAP2-mediated transcriptional activation. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Stimulates the peroxisome proliferator-activated receptors PPARA transcriptional activity. Enhances estrogen-dependent transactivation mediated by estrogen receptors. Also acts as a transcriptional corepressor; interferes with the binding of the transcription factors HIF1A or STAT2 and the p300/CBP transcriptional coactivator complex. Participates in sex determination and early gonad development by stimulating transcription activation of SRY. Plays a role in controlling left-right patterning during embryogenesis; potentiates transcriptional activation of NODAL-mediated gene transcription in the left lateral plate mesoderm (LPM). Plays an essential role in differentiation of the adrenal cortex from the adrenogonadal primordium (AGP); stimulates WT1-mediated transcription activation thereby up-regulating the nuclear hormone receptor NR5A1 promoter activity. Associates with chromatin to the PITX2 P1 promoter region.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.