AP-1 Immediate Early Response
Gene co-expression module in Gamma-delta T cells
| Category | Stress |
|---|---|
| Genes | 34 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 13 of 34 genes have a known function matching the annotation |
Why this annotation
Top hub genes are GADD45B (DNA damage/stress-inducible gene), HEXIM1 (inhibitor of P-TEFb elongation complex, transcriptional stress), JUNB and JUN (AP-1 transcription factors, immediate early response), IER2 (immediate early response gene 2), CITED2 (hypoxia/stress-responsive coactivator), SGK1 (stress-activated kinase), RASD1 (immediate early gene), TNF (pro-inflammatory cytokine), SNAI1 (stress/EMT TF). The module is a well-defined immediate early / AP-1 stress-response program. HEXIM1 coupling to JUNB/JUN supports transcriptional pause-release under stimulation. Strong coherence and uniform expression support a broadly activated stress-response program in gd T cells.
Genes
BRD2, CITED2, CSKMT, EGR1, EIF4A2, FRAT1, FRAT2, GADD45B, HEXIM1, ID2, IER2, IER3, IER5L, INTS6, JUN, JUNB, MARCKSL1, MEPCE, MYLIP, NUFIP2, NXF1, PLK2, PTCH2, RASD1, SDR42E2, SGK1, SLC38A2, SNAI1, TBCC, TLE4, TMEM107, TNF, TUBA1A, WDR74
Most correlated modules
- Heat Stress Apoptotic · correlation 0.76
- Polycomb Transcriptional Control · correlation 0.57
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.