EGR1 — Early growth response 1

EGR1 belongs to a gene co-expression module in 15 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

EGR1's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	Immediate Early NFkB BCR/AP1/NFKb pathway	ARL5B, CDKN1A, CSRNP1, DUSP2, EGR3, IER2, NFKBIA, PPP1R15B +3 more	View in SCUBA
CD4⁺ T cells	Immediate Early AP-1 TCR/AP1/NFKb pathway	BTG2, CD69, CDKN1A, DUSP1, FOS, FOSB, IER2, IER5 +6 more	View in SCUBA
CD8⁺ T cells	AP-1 Early Activation TCR Signaling	BTG2, CD69, FOS, FOSB, IER2, JUNB, LEPROTL1, LITAF +5 more	View in SCUBA
Endothelial	Shear Stress Response Stress	DNAJB1, DUSP1, FOS, FOSB, HES1, HSP90AA1, HSPA1A, HSPA1B +11 more	View in SCUBA
Gamma-delta T cells	AP-1 Immediate Early Response Stress	BRD2, CITED2, CSKMT, EIF4A2, FRAT1, FRAT2, GADD45B, HEXIM1 +25 more
Glial cells	Immediate Early Gene Response Activation	DNAJB1, FOS, FOSB, HES1, HSP90AA1, HSPA1A, HSPA1B, IER2 +3 more	View in SCUBA
Goblet cells	Immediate Early Gene chromatin regulation & transcription	BTG2, DUSP1, FOS, FOSB, IER2, JUN, JUNB, JUND	View in SCUBA
Innate lymphoid cells	Immediate Early Response activation	ATF3, BRD2, BTG2, CCNL1, DDX3X, DNAJA1, EIF4A3, EIF5 +8 more	View in SCUBA
Lymphatic endothelial	AP-1 Immediate Early Inflammation	DUSP1, FOS, FOSB, HES1, HSPA8, IER2, JUN, JUNB +7 more	View in SCUBA
Macrophages	Early response genes Inflammatory	ATF3, BAG3, BTG2, CGAS, DNAJA1, DNAJA4, DNAJB1, DNAJB4 +39 more	View in SCUBA
Monocytes	Immediate-Early Inflammatory Inflammatory	CXCL2, CXCL3, CXCL8, DUSP2, EGR2, NFKBIA, NFKBIZ, OTUD1 +3 more	View in SCUBA
Mucosal-associated invariant T cell	TCR-Induced Early Response TCR Signaling	ATF3, GLA, HMGCS1, IER3, NR4A1, NUP58, PPP1R15B, RHOB +3 more
Neutrophils	Immediate Early Response Stress	ADM, BTG2, DUSP1, FOS, IER2, JUNB, ZFP36
Pericytes	Immediate Early Gene Stress	DNAJB1, FOS, FOSB, HSPA1A, HSPA1B, IER2, JUN, JUNB +3 more	View in SCUBA
Smooth muscle cells	Immediate Early Response Stress	ATF3, BTG1, BTG2, CDKN1A, FOS, GADD45B, HES1, IER2 +7 more	View in SCUBA

About the gene

Synonyms	225, AT225, G0S30, KROX-24, NGFI-A, TIS8, ZIF-268
Chromosome	5: 138465479-138469303
Predicted location	Intracellular
Essential gene	No
Protein class	Cancer-related genes, Plasma proteins, Predicted intracellular proteins, Transcription factors
Molecular function	Activator, DNA-binding
Biological process	Biological rhythms, Transcription, Transcription regulation

Function

Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (By similarity). Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Activates expression of p53/TP53 and TGFB1, and thereby helps prevent tumor formation. Required for normal progress through mitosis and normal proliferation of hepatocytes after partial hepatectomy. Mediates responses to ischemia and hypoxia; regulates the expression of proteins such as IL1B and CXCL2 that are involved in inflammatory processes and development of tissue damage after ischemia. Regulates biosynthesis of luteinizing hormone (LHB) in the pituitary (By similarity). Regulates the amplitude of the expression rhythms of clock genes: BMAL1, PER2 and NR1D1 in the liver via the activation of PER1 (clock repressor) transcription. Regulates the rhythmic expression of core-clock gene BMAL1 in the suprachiasmatic nucleus (SCN) (By similarity).

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.