G6PD — Glucose-6-phosphate dehydrogenase
G6PD belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
G6PD's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | Osmotic Stress Response Stress | ANKRD28, BZW1, CD109, CXCL8, CYB5R4, CYTIP, DUSP4, EMP3 +25 more | View in SCUBA |
| Monocytes | Pentose Phosphate Pathway Innate immunity | ACAP1, AP5B1, CCDC69, CCND3, CITED4, CORO2A, DYSF, EIF4E3 +4 more | View in SCUBA |
About the gene
| Synonyms | G6PD1 |
|---|---|
| Chromosome | X: 154517825-154547572 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Oxidoreductase |
| Biological process | Carbohydrate metabolism, Glucose metabolism |
Function
Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.