CYB5R4 — Cytochrome b5 reductase 4
CYB5R4 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CYB5R4's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Rho GTPase Signaling Cytoskeletal | APOBR, ARHGEF3, ATP6V1H, BRCC3, CD46, CNDP2, DCTN5, DNMT3A +14 more | |
| Macrophages | Osmotic Stress Response Stress | ANKRD28, BZW1, CD109, CXCL8, CYTIP, DUSP4, EMP3, FURIN +25 more | View in SCUBA |
About the gene
| Synonyms | b5+b5R, dJ676J13.1, NCB5OR |
|---|---|
| Chromosome | 6: 83859656-83967423 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted intracellular proteins |
| Molecular function | Oxidoreductase |
Function
NADH-cytochrome b5 reductase involved in endoplasmic reticulum stress response pathway. Plays a critical role in protecting pancreatic beta-cells against oxidant stress, possibly by protecting the cell from excess buildup of reactive oxygen species (ROS). Reduces a variety of substrates in vitro, such as cytochrome c, feericyanide and methemoglobin
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.