Osmotic Stress Response
Gene co-expression module in Macrophages
| Category | Stress |
|---|---|
| Genes | 34 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 10 of 34 genes have a known function matching the annotation |
Why this annotation
Hub genes include SLC5A3 (myo-inositol transporter, osmolyte), SLC6A6 (taurine transporter, osmolyte), PGD (pentose phosphate/NADPH), UPP1 (nucleotide salvage), SLC16A6 (monocarboxylate transporter), PHLDA1 (stress-induced), FURIN (proprotein convertase), CYTIP (integrin signaling), MMP19. The combination of osmolyte transporters (SLC5A3, SLC6A6), metabolic enzymes (PGD, GK), and stress-response genes (PHLDA1) in mono_mac-enriched cells suggests an osmotic/metabolic stress adaptation program in monocyte-derived macrophages. All genes show weak membership and the module has unknown coherence, indicating a loosely coupled program.
Genes
ANKRD28, BZW1, CD109, CXCL8, CYB5R4, CYTIP, DUSP4, EMP3, FURIN, G6PD, GK, LAT, LRP12, MMP19, MTHFD2L, P2RX4, PDE4DIP, PEDS1, PGD, PHLDA1, PSMD11, RIT1, SATB1, SEC22B, SLC16A6, SLC5A3, SLC6A6, TLNRD1, TMEM120A, TPD52L2, UBE2A, UPP1, VDR, WIPI1
Most correlated modules
- Monocyte Innate Signaling · correlation 0.90
- NRF2 Oxidative Stress · correlation 0.89
- Inflammatory Monocyte Activation · correlation 0.87
- RNA Processing Housekeeping · correlation 0.86
- Monocyte Lipid Metabolism · correlation 0.85
- Lipid-Sensing Transcriptional · correlation 0.84
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.