GABRD — Gamma-aminobutyric acid type A receptor subunit delta
GABRD belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
GABRD's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | VEGF Tip Cell Signaling Endothelial cell development | ADAMTS5, BDKRB2, CA2, CBLB, CCND1, DGKD, ESM1, GNAI1 +7 more | View in SCUBA |
About the gene
| Chromosome | 1: 2019329-2030758 |
|---|---|
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Disease related genes, FDA approved drug targets, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Chloride channel, Ion channel |
| Biological process | Ion transport, Transport |
Function
Delta subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain. GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient. GABAARs containing delta/GABRD subunits are predominantly located in extrasynaptic or perisynaptic positions on hippocampus and cerebellar granule cells, and contribute to the tonic GABAergic inhibition (By similarity). GABAAR containing alpha-4-beta-3-delta subunits can simultaneously bind GABA and histamine where histamine binds at the interface of two neighboring beta subunits, which may be involved in the regulation of sleep and wakefulness.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.