VEGF Tip Cell Signaling
Gene co-expression module in Endothelial
| Category | Endothelial cell development |
|---|---|
| Genes | 16 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 16 genes have a known function matching the annotation |
Why this annotation
ESM1 (endocan) and SPRY4 are canonical VEGF-induced tip cell markers in endothelial biology. BDKRB2 (bradykinin receptor B2) mediates inflammatory vascular permeability and angiogenesis. GNAI1 (Gi-alpha) and DGKD (diacylglycerol kinase delta) participate in GPCR/lipid signaling downstream of angiogenic cues. RGCC (regulator of cell cycle) is expressed in endothelial cells responding to VEGF. CCND1 (cyclin D1) supports proliferative angiogenic response. CBLB is an E3 ligase that modulates receptor tyrosine kinase signaling. CA2 (carbonic anhydrase II) is involved in pH regulation in angiogenic contexts. ADAMTS5 remodels ECM during sprouting. The moderate UC inflammation signal with non-significant CD response suggests a VEGF-driven angiogenic program.
Genes
ADAMTS5, BDKRB2, CA2, CBLB, CCND1, DGKD, ESM1, GABRD, GNAI1, IVNS1ABP, PHLDB1, RGCC, SINHCAF, SPRY4, SUSD6, TMEM233
Most correlated modules
- Inflammatory EC Activation · correlation 0.79
- Basement Membrane Assembly · correlation 0.77
- Angiogenic Endothelial Identity · correlation 0.77
- Actomyosin Contractility · correlation 0.75
- ECM Fibrotic Remodeling · correlation 0.74
- CXCL12 Angiogenic Chemotaxis · correlation 0.72
- Coagulation Protease Signaling · correlation 0.70
- Vascular Barrier Integrity · correlation 0.68
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.