GNAI1 — G protein subunit alpha i1
GNAI1 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
GNAI1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | VEGF Tip Cell Signaling Endothelial cell development | ADAMTS5, BDKRB2, CA2, CBLB, CCND1, DGKD, ESM1, GABRD +7 more | View in SCUBA |
| Fibroblasts | IL-1 Receptor Signaling Inflammatory | CHIC2, IL1R1, MMD, PDLIM1, PRR16, SMIM3, ST3GAL1, TUSC3 | View in SCUBA |
| Hematopoietic progenitor cells | Quiescent HSC State Stemness | ARHGEF17, BAALC, BIN1, CD52, HOPX, MZB1, RBPMS, SPINK2 |
About the gene
| Chromosome | 7: 79768028-80226181 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Hydrolase, Transducer |
| Biological process | Cell cycle, Cell division, Host-virus interaction, Mitosis, Transport |
Function
Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins. Signaling is mediated via effector proteins, such as adenylate cyclase: inhibits adenylate cyclase activity of ADCY1, ADCY5 and ADCY6, leading to decreased intracellular cAMP levels. The inactive GDP- bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. Required for normal cytokinesis during mitosis. Required for cortical dynein-dynactin complex recruitment during metaphase.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.