CA2 — Carbonic anhydrase 2
CA2 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CA2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Th17/MAIT type-17 Th17 fate | AKT1S1, CA10, CCL20, CEBPD, GFPT2, IL22, IL4I1, LRRN3 +9 more | View in SCUBA |
| Endothelial | VEGF Tip Cell Signaling Endothelial cell development | ADAMTS5, BDKRB2, CBLB, CCND1, DGKD, ESM1, GABRD, GNAI1 +7 more | View in SCUBA |
| Innate lymphoid cells | Dissociation Stress Response Stress | C12orf57, CALM2, EHD1, EIF4A2, IER2, MEPCE, NDRG1, NUDT4 +9 more | View in SCUBA |
| Macrophages | Oxidative Metabolic Program Mitochondrial & OxPhos | ACADM, CALM3, CAPG, COQ2, CSRP1, CSTB, DENND2D, EIF4EBP1 +29 more | View in SCUBA |
| Mucosal-associated invariant T cell | Tissue Residency Regulation Tissue residence | ABCC1, ANKRD28, ARHGEF7, CDV3, CHD7, CYTIP, IL18R1, JMY +4 more |
About the gene
| Synonyms | CA-II, CAII, Car2 |
|---|---|
| Chromosome | 8: 85463968-85481493 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Lyase |
Function
Catalyzes the reversible hydration of carbon dioxide. Can also hydrate cyanamide to urea. Stimulates the chloride-bicarbonate exchange activity of SLC26A6. Essential for bone resorption and osteoclast differentiation. Involved in the regulation of fluid secretion into the anterior chamber of the eye. Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.