GNL2 — G protein nucleolar 2
GNL2 belongs to a gene co-expression module in 1 of 30 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
GNL2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Colonocytes | Chromatin-Coupled Splicing chromatin regulation & transcription | ABCF1, ARID1B, ATAD5, BAZ1B, BPTF, BTAF1, CHEK2, CKAP5 +36 more | View in SCUBA |
About the gene
| Synonyms | HUMAUANTIG, Ngp-1, Nog2, Nug2 |
|---|---|
| Chromosome | 1: 37566816-37595937 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins |
| Biological process | Ribosome biogenesis |
Function
GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. May promote cell proliferation possibly by increasing p53/TP53 protein levels, and consequently those of its downstream product CDKN1A/p21, and decreasing RPL23A protein levels.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.